Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial

BACKGROUND: The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin clearance is postulated to improve protamine dosing precision and coagulation. We...

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Publicado en:PLoS Med
Main Authors: Miles, Lachlan F., Burt, Christiana, Arrowsmith, Joseph, McKie, Mikel A., Villar, Sofia S., Govender, Pooveshnie, Shaylor, Ruth, Tan, Zihui, De Silva, Ravi, Falter, Florian
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216535/
https://ncbi.nlm.nih.gov/pubmed/34097705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003658
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