Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides

Oligonucleotide-based therapeutics have the capacity to engage with nucleic acid immune sensors to activate or block their response, but a detailed understanding of these immunomodulatory effects is currently lacking. We recently showed that 2′-O-methyl (2′OMe) gapmer antisense oligonucleotides (ASO...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Valentin, Roxane, Wong, Christophe, Alharbi, Arwaf S, Pradeloux, Solène, Morros, Makala P, Lennox, Kim A, Ellyard, Julia I, Garcin, Aurélie J, Ullah, Tomalika R, Kusuma, Gina D, Pépin, Geneviève, Li, Hong-Mei, Pearson, Jaclyn S, Ferrand, Jonathan, Lim, Rebecca, Veedu, Rakesh N, Morand, Eric F, Vinuesa, Carola G, Behlke, Mark A, Gantier, Michael P
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216285/
https://ncbi.nlm.nih.gov/pubmed/34057477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab451
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