Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth

Cyclophosphamide (CTX) is widely used in various cancer therapies and in immunosuppression, and patients can still have babies after CTX chemotherapy. CTX directly causes primordial follicle loss with overactivation and DNA damage-induced apoptosis. Previous studies have shown that maternal exposure...

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Bibliografiska uppgifter
I publikationen:Front Cell Dev Biol
Huvudupphovsmän: Yang, Weijie, Ma, Yerong, Jin, Jiamin, Ren, Peipei, Zhou, Hanjing, Xu, Shiqian, Zhang, Yingyi, Hu, Zhanhong, Rong, Yan, Dai, Yongdong, Zhang, Yinli, Zhang, Songying
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Cell and Developmental Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215553/
https://ncbi.nlm.nih.gov/pubmed/34164401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.682060
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