Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK

STUDY QUESTION: Does metformin inhibit excessive androgen-induced endoplasmic reticulum (ER) stress in mouse granulosa cells (GCs) in vivo and in vitro? SUMMARY ANSWER: Metformin inhibits testosterone-induced ER stress and unfolded protein response (UPR) activation by suppressing p38 MAPK phosphoryl...

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Detalhes bibliográficos
Publicado no:Hum Reprod
Main Authors: Jin, Jiamin, Ma, Yerong, Tong, Xiaomei, Yang, Weijie, Dai, Yongdong, Pan, Yibin, Ren, Peipei, Liu, Liu, Fan, Heng-Yu, Zhang, Yinli, Zhang, Songying
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259369/
https://ncbi.nlm.nih.gov/pubmed/32372097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/deaa077
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