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Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein–coupled receptor signaling to MAPK

After activation of G protein–coupled receptors, G protein βγ dimers may translocate from the plasma membrane to the Golgi apparatus (GA). We recently report that this translocation activates extracellular signal–regulated protein kinases 1 and 2 (ERK1/2) via PI3Kγ; however, how Gβγ–PI3Kγ activates...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Khater, Mostafa, Bryant, Christian N., Wu, Guangyu
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215300/
https://ncbi.nlm.nih.gov/pubmed/34022220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100805
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