T(reg) deficiency‐mediated T(H)1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells

Immune dysregulation has long been proposed as a component of premature ovarian insufficiency (POI), but the underlying mediators and mechanisms remain largely unknown. Here we showed that patients with POI had augmented T helper 1 (T(H)1) responses and regulatory T (T(reg)) cell deficiency in both...

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Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Jiao, Xue, Zhang, Xiruo, Li, Nianyu, Zhang, Dunfang, Zhao, Shidou, Dang, Yujie, Zanvit, Peter, Jin, Wenwen, Chen, Zi‐Jiang, Chen, Wanjun, Qin, Yingying
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214854/
https://ncbi.nlm.nih.gov/pubmed/34185428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.448
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