Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity

The toxic metalloid arsenic causes widespread misfolding and aggregation of cellular proteins. How these protein aggregates are formed in vivo, the mechanisms by which they affect cells and how cells prevent their accumulation is not fully understood. To find components involved in these processes,...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Andersson, Stefanie, Romero, Antonia, Rodrigues, Joana Isabel, Hua, Sansan, Hao, Xinxin, Jacobson, Therese, Karl, Vivien, Becker, Nathalie, Ashouri, Arghavan, Rauch, Sebastien, Nyström, Thomas, Liu, Beidong, Tamás, Markus J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214759/
https://ncbi.nlm.nih.gov/pubmed/34085697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.258338
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