Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity

The toxic metalloid arsenic causes widespread misfolding and aggregation of cellular proteins. How these protein aggregates are formed in vivo, the mechanisms by which they affect cells and how cells prevent their accumulation is not fully understood. To find components involved in these processes,...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Principais autores: Andersson, Stefanie, Romero, Antonia, Rodrigues, Joana Isabel, Hua, Sansan, Hao, Xinxin, Jacobson, Therese, Karl, Vivien, Becker, Nathalie, Ashouri, Arghavan, Rauch, Sebastien, Nyström, Thomas, Liu, Beidong, Tamás, Markus J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214759/
https://ncbi.nlm.nih.gov/pubmed/34085697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.258338
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