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Mechanism of genome instability mediated by human DNA polymerase mu misincorporation
Pol μ is capable of performing gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Together with DNA ligase, misincorporation of dGTP opposite the templating T by Pol μ results in a promutagenic T:G mispair, leading to genomic instability. Here, crystal structures and kinet...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8213813/ https://ncbi.nlm.nih.gov/pubmed/34145298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24096-7 |
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