Mechanism of genome instability mediated by human DNA polymerase mu misincorporation

Pol μ is capable of performing gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Together with DNA ligase, misincorporation of dGTP opposite the templating T by Pol μ results in a promutagenic T:G mispair, leading to genomic instability. Here, crystal structures and kinet...

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Vydáno v:Nat Commun
Hlavní autoři: Guo, Miao, Wang, Yina, Tang, Yuyue, Chen, Zijing, Hou, Jinfeng, Dai, Jingli, Wang, Yudong, Wang, Liangyan, Xu, Hong, Tian, Bing, Hua, Yuejin, Zhao, Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213813/
https://ncbi.nlm.nih.gov/pubmed/34145298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24096-7
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