Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

The glucagon-like peptide-1 (GLP-1) receptor is a validated drug target for metabolic disorders. Ago-allosteric modulators are capable of acting both as agonists on their own and as efficacy enhancers of orthosteric ligands. However, the molecular details of ago-allosterism remain elusive. Here, we...

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Publicado no:Nat Commun
Main Authors: Cong, Zhaotong, Chen, Li-Nan, Ma, Honglei, Zhou, Qingtong, Zou, Xinyu, Ye, Chenyu, Dai, Antao, Liu, Qing, Huang, Wei, Sun, Xianqiang, Wang, Xi, Xu, Peiyu, Zhao, Lihua, Xia, Tian, Zhong, Wenge, Yang, Dehua, Eric Xu, H., Zhang, Yan, Wang, Ming-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213797/
https://ncbi.nlm.nih.gov/pubmed/34145245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24058-z
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