Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis

OBJECTIVE: Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a BMP antagonist that is developmentally regulated and we sought to in...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Duffy, Laura, Henderson, John, Brown, Max, Pryzborski, Stefan, Fullard, Nicola, Summa, Lena, Distler, Jorg H. W., Stratton, Richard, O’Reilly, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213337/
https://ncbi.nlm.nih.gov/pubmed/34150776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.681061
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