Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity

Dynamically shifting protein-protein interactions (PPIs) regulate cellular responses to viruses and the resulting immune signaling. Here, we use thermal proximity coaggregation (TPCA) mass spectrometry to characterize the on-off behavior of PPIs during infection with herpes simplex virus 1 (HSV-1),...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Justice, Joshua L., Kennedy, Michelle A., Hutton, Josiah E., Liu, Dawei, Song, Bokai, Phelan, Brett, Cristea, Ileana M.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213230/
https://ncbi.nlm.nih.gov/pubmed/34144993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg6680
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