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Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses. Despite being predominantly nuclear, IFI16 can unexpectedly sense pa...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3387042/ https://ncbi.nlm.nih.gov/pubmed/22691496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203447109 |
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