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Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses. Despite being predominantly nuclear, IFI16 can unexpectedly sense pa...

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Bibliografiset tiedot
Päätekijät: Li, Tuo, Diner, Benjamin A., Chen, Jin, Cristea, Ileana M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387042/
https://ncbi.nlm.nih.gov/pubmed/22691496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203447109
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