Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing

BACKGROUND: With increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient production processes of these “off-the-shelf” therapeutics. In order to ensure safety and prevent the occurrence of secondary tumors, (CAR-)NK-9...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Walcher, Lia, Kistenmacher, Ann-Kathrin, Sommer, Charline, Böhlen, Sebastian, Ziemann, Christina, Dehmel, Susann, Braun, Armin, Tretbar, Uta Sandy, Klöß, Stephan, Schambach, Axel, Morgan, Michael, Löffler, Dennis, Kämpf, Christoph, Blumert, Conny, Reiche, Kristin, Beckmann, Jana, König, Ulla, Standfest, Bastian, Thoma, Martin, Makert, Gustavo R., Ulbert, Sebastian, Kossatz-Böhlert, Uta, Köhl, Ulrike, Dünkel, Anna, Fricke, Stephan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212864/
https://ncbi.nlm.nih.gov/pubmed/34149724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.684052
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