Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT‐1: Influence on (18)F‐FDG PET Uptake

Positron emission tomography (PET) using 2‐deoxy‐2‐[(18)F]fluoro‐d‐glucose ([(18)F]FDG), a marker of energy metabolism and cell proliferation, is routinely used in the clinic to assess patient response to chemotherapy and to monitor tumor growth. Treatment with some tyrosine kinase inhibitors (TKIs)...

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Veröffentlicht in:Clin Transl Sci
Hauptverfasser: Damaraju, Vijaya L., Aminpour, Maral, Kuzma, Michelle, Winter, Philip, Preto, Jordane, Tuszynski, Jack, McEwan, Alexander B.J., Sawyer, Michael B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212708/
https://ncbi.nlm.nih.gov/pubmed/33278334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12943
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