Therapeutic potential of NTRK3 inhibition in desmoplastic small round cell tumor

PURPOSE: Desmoplastic small round cell tumor (DSRCT) is a highly lethal intra-abdominal sarcoma of adolescents and young adults. DSRCT harbors a t(11;22)(p13:q12) that generates the EWSR1-WT1 chimeric transcription factor, the key oncogenic driver of DSRCT. EWSR1-WT1 rewires global gene expression n...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Ogura, Koichi, Somwar, Romel, Hmeljak, Julija, Magnan, Heather, Benayed, Ryma, Boroujeni, Amir Momeni, Bowman, Anita S., Mattar, Marissa S., Khodos, Inna, de Stanchina, Elisa, Jungbluth, Achim, Asher, Marina, Odintsov, Igor, Hartono, Alifiani B., LaQuaglia, Michael P., Slotkin, Emily, Pratilas, Christine A., Lee, Sean Bong, Spraggon, Lee, Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212565/
https://ncbi.nlm.nih.gov/pubmed/33229458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2585
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