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Efficient precise in vivo base editing in adult dystrophic mice
Recent advances in base editing have created an exciting opportunity to precisely correct disease-causing mutations. However, the large size of base editors and their inherited off-target activities pose challenges for in vivo base editing. Moreover, the requirement of a protospacer adjacent motif (...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8211797/ https://ncbi.nlm.nih.gov/pubmed/34140489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23996-y |
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