Cardiolipin remodeling defects impair mitochondrial architecture and function in a murine model of Barth syndrome cardiomyopathy

BACKGROUND: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin (TAZ), encoding a mitochondrial acyltransferase required for cardiolipin (CL) remodeling. Despite recent description of a mouse model of BTHS card...

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Detalhes bibliográficos
Publicado no:Circ Heart Fail
Main Authors: Zhu, Siting, Chen, Ze’e, Zhu, Mason, Shen, Ying, Leon, Leonardo J, Chi, Liguo, Spinozzi, Simone, Tan, Changming, Gu, Yusu, Nguyen, Anh, Zhou, Yi, Feng, Wei, Vaz, Frédéric M, Wang, Xiaohong, Gustafsson, Asa B, Evans, Sylvia M, Kunfu, Ouyang, Fang, Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210459/
https://ncbi.nlm.nih.gov/pubmed/34129362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.008289
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