Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

BACKGROUND: Genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with increased risk for intracranial aneurysm (IA). However, how such variants affect gene expression within IA is poorly understood. We used publicly-available ChIP-Seq data to study c...

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Vydáno v:BMC Med Genomics
Hlavní autoři: Poppenberg, Kerry E., Zebraski, Haley R., Avasthi, Naval, Waqas, Muhammad, Siddiqui, Adnan H., Jarvis, James N., Tutino, Vincent M.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210394/
https://ncbi.nlm.nih.gov/pubmed/34134708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-021-01007-9
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