The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core

Genome instability is a characteristic enabling factor for carcinogenesis. HelQ helicase is a component of human DNA maintenance systems that prevent or reverse genome instability arising during DNA replication. Here, we provide details of the molecular mechanisms that underpin HelQ function—its rec...

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Detalles Bibliográficos
Publicado en:NAR Cancer
Autores principales: Jenkins, Tabitha, Northall, Sarah J, Ptchelkine, Denis, Lever, Rebecca, Cubbon, Andrew, Betts, Hannah, Taresco, Vincenzo, Cooper, Christopher D O, McHugh, Peter J, Soultanas, Panos, Bolt, Edward L
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210318/
https://ncbi.nlm.nih.gov/pubmed/34316696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa043
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