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The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis
DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well-documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymatic activity and anti-ferroptosis effect. It has been shown that DJ-1 forms the homodi...
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| Pubblicato in: | Acta Pharmacol Sin |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Singapore
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8209194/ https://ncbi.nlm.nih.gov/pubmed/33024240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-00531-1 |
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