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Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog
Decreasing the partition coefficient (LogP) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. Since melting point is related to aqueous solubility, we and other groups have developed alternati...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8209153/ https://ncbi.nlm.nih.gov/pubmed/34135380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92028-y |
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