Extraction of rapid kinetics from smFRET measurements using integrative detectors

Hidden Markov models (HMMs) are used to learn single-molecule kinetics across a range of experimental techniques. By their construction, HMMs assume that single-molecule events occur on slower timescales than those of data acquisition. To move beyond that HMM limitation and allow for single-molecule...

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Bibliographic Details
Published in:Cell Rep Phys Sci
Main Authors: Kilic, Zeliha, Sgouralis, Ioannis, Heo, Wooseok, Ishii, Kunihiko, Tahara, Tahei, Pressé, Steve
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208598/
https://ncbi.nlm.nih.gov/pubmed/34142102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrp.2021.100409
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