The Ras dimer structure

Oncogenic mutated Ras is a key player in cancer, but despite intense and expensive approaches its catalytic center seems undruggable. The Ras dimer interface is a possible alternative drug target. Dimerization at the membrane affects cell growth signal transduction. In vivo studies indicate that pre...

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Udgivet i:Chem Sci
Main Authors: Rudack, Till, Teuber, Christian, Scherlo, Marvin, Güldenhaupt, Jörn, Schartner, Jonas, Lübben, Mathias, Klare, Johann, Gerwert, Klaus, Kötting, Carsten
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2021
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208300/
https://ncbi.nlm.nih.gov/pubmed/34194708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00957e
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