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A computational approach for detecting physiological homogeneity in the midst of genetic heterogeneity
The human genetic dissection of clinical phenotypes is complicated by genetic heterogeneity. Gene burden approaches that detect genetic signals in case-control studies are underpowered in genetically heterogeneous cohorts. We therefore developed a genome-wide computational method, network-based hete...
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| Publicado no: | Am J Hum Genet |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8206396/ https://ncbi.nlm.nih.gov/pubmed/34015270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.04.023 |
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