A computational approach for detecting physiological homogeneity in the midst of genetic heterogeneity

The human genetic dissection of clinical phenotypes is complicated by genetic heterogeneity. Gene burden approaches that detect genetic signals in case-control studies are underpowered in genetically heterogeneous cohorts. We therefore developed a genome-wide computational method, network-based hete...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Am J Hum Genet
Κύριοι συγγραφείς: Zhang, Peng, Cobat, Aurélie, Lee, Yoon-Seung, Wu, Yiming, Bayrak, Cigdem Sevim, Boccon-Gibod, Clémentine, Matuozzo, Daniela, Lorenzo, Lazaro, Jain, Aayushee, Boucherit, Soraya, Vallée, Louis, Stüve, Burkhard, Chabrier, Stéphane, Casanova, Jean-Laurent, Abel, Laurent, Zhang, Shen-Ying, Itan, Yuval
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2021
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206396/
https://ncbi.nlm.nih.gov/pubmed/34015270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.04.023
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