Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWASs). However, it is now common for researchers to have acc...

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Udgivet i:Am J Hum Genet
Main Authors: Albiñana, Clara, Grove, Jakob, McGrath, John J., Agerbo, Esben, Wray, Naomi R., Bulik, Cynthia M., Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Børglum, Anders D., Mortensen, Preben Bo, Privé, Florian, Vilhjálmsson, Bjarni J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206385/
https://ncbi.nlm.nih.gov/pubmed/33964208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.04.014
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