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A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival
XBP1 is a basic leucine zipper (bZIP) transcription factor and a key mediator of the endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR). XBP1-mediated transcription facilitates cell adaptation to ER stress and also promotes tumor progression, while suppressing anti-tumor imm...
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| Publicado no: | Biochem Biophys Res Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8206033/ https://ncbi.nlm.nih.gov/pubmed/34038755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2021.05.038 |
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