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A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival

XBP1 is a basic leucine zipper (bZIP) transcription factor and a key mediator of the endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR). XBP1-mediated transcription facilitates cell adaptation to ER stress and also promotes tumor progression, while suppressing anti-tumor imm...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Zhong, Yongwang, Yan, Wenjing, Ruan, Jingjing, Fang, Mike, Lapidus, Rena G., Du, Shaojun, Fang, Shengyun
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206033/
https://ncbi.nlm.nih.gov/pubmed/34038755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2021.05.038
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