Pervasive cis effects of variation in copy number of large tandem repeats on local DNA methylation and gene expression

Variable number tandem repeats (VNTRs) are composed of large tandemly repeated motifs, many of which are highly polymorphic in copy number. However, because of their large size and repetitive nature, they remain poorly studied. To investigate the regulatory potential of VNTRs, we used read-depth dat...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Garg, Paras, Martin-Trujillo, Alejandro, Rodriguez, Oscar L., Gies, Scott J., Hadelia, Elina, Jadhav, Bharati, Jain, Miten, Paten, Benedict, Sharp, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206010/
https://ncbi.nlm.nih.gov/pubmed/33794196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.03.016
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