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Engineering ‘Enzymelink’ for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity
AIM: This study investigated our Enzymelinks, COX-2-10aa-mPGES-1 and COX-2-10aa-PGIS, as cellular cross-screening targets for quick identification of lead compounds to inhibit inflammatory PGE(2) biosynthesis while maintaining prostacyclin synthesis. METHODS: We integrated virtual and wet cross-scre...
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| 出版年: | Future Med Chem |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Newlands Press Ltd
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8204920/ https://ncbi.nlm.nih.gov/pubmed/34080888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2021-0056 |
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