Structural basis of TRAPPIII‐mediated Rab1 activation

The GTPase Rab1 is a master regulator of the early secretory pathway and is critical for autophagy. Rab1 activation is controlled by its guanine nucleotide exchange factor, the multisubunit TRAPPIII complex. Here, we report the 3.7 Å cryo‐EM structure of the Saccharomyces cerevisiae TRAPPIII complex...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Joiner, Aaron MN, Phillips, Ben P, Yugandhar, Kumar, Sanford, Ethan J, Smolka, Marcus B, Yu, Haiyuan, Miller, Elizabeth A, Fromme, J Christopher
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204860/
https://ncbi.nlm.nih.gov/pubmed/34018207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020107607
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