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In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains

BACKGROUND: Mutations in PRESENILIN 2 (PSEN2) cause early onset familial Alzheimer’s disease (EOfAD) but their mode of action remains elusive. One consistent observation for all PRESENILIN gene mutations causing EOfAD is that a transcript is produced with a reading frame terminated by the normal sto...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Alzheimers Dis Rep
Egile Nagusiak: Barthelson, Karissa, Pederson, Stephen Martin, Newman, Morgan, Jiang, Haowei, Lardelli, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: IOS Press 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203281/
https://ncbi.nlm.nih.gov/pubmed/34189411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-200279
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