Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi Syndrome (PWS) retain the molecular signature of PWS

Prader-Willi syndrome (PWS) is a syndromic obesity caused by loss of paternal gene expression in an imprinted interval on 15q11.2-q13. Induced pluripotent stem cells were generated from skin cells of three large deletion PWS patients and one unique microdeletion PWS patient. We found that genes with...

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Bibliografiska uppgifter
I publikationen:Stem Cell Res
Huvudupphovsmän: Burnett, Lisa C., LeDuc, Charles A., Sulsona, Carlos R., Paull, Daniel, Eddiry, Sanaa, Levy, Brynn, Salles, Jean Pierre, Tauber, Maithe, Driscoll, Daniel J., Egli, Dieter, Leibel, Rudolph L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202351/
https://ncbi.nlm.nih.gov/pubmed/27789403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2016.08.008
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