Structure–Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile

[Image: see text] Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its ability to form spores, which are not susceptible to an...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Speri, Enrico, Qian, Yuanyuan, Janardhanan, Jeshina, Masitas, Cesar, Lastochkin, Elena, De Benedetti, Stefania, Wang, Man, Schroeder, Valerie A., Wolter, William R., Oliver, Allen G., Fisher, Jed F., Mobashery, Shahriar, Chang, Mayland
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201750/
https://ncbi.nlm.nih.gov/pubmed/34141083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00135
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