Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing

Aims: To investigate the role of KCa3. 1 inhibition in macrophage pro-inflammatory polarization and vulnerability to atrial fibrillation (AF) in a canine model with prolonged rapid atrial pacing. Materials and Methods: Twenty beagle dogs (weighing 8–10 kg) were randomly assigned to a sham group (n =...

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Bibliographic Details
Published in:Front Cardiovasc Med
Main Authors: He, Shanqing, Wang, Youcheng, Yao, Yajun, Cao, Zhen, Yin, Junkui, Zi, Liuliu, Chen, Huiyu, Fu, Yuntao, Wang, Xi, Zhao, Qingyan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cardiovascular Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8200470/
https://ncbi.nlm.nih.gov/pubmed/34136541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.656631
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