Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

The interaction of multi-LacNAc (Galβ1-4GlcNAc)-containing N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers with human galectin-1 (Gal-1) and the carbohydrate recognition domain (CRD) of human galectin-3 (Gal-3) was analyzed using NMR methods in addition to cryo-electron-microscopy and dynamic l...

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Publicat a:Int J Mol Sci
Autors principals: Bertuzzi, Sara, Gimeno, Ana, Martinez-Castillo, Ane, Lete, Marta G., Delgado, Sandra, Airoldi, Cristina, Rodrigues Tavares, Marina, Bláhová, Markéta, Chytil, Petr, Křen, Vladimír, Abrescia, Nicola G. A., Ardá, Ana, Bojarová, Pavla, Jiménez-Barbero, Jesús
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199549/
https://ncbi.nlm.nih.gov/pubmed/34206141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22116000
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