Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Opioids are the most effective analgesics, with most clinically available opioids being agonists to the µ-opioid receptor (MOR). The MOR is also responsible for their unwanted effects, including reward and opioid misuse leading to the current public health crisis. The imperative need for safer, non-...

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Publicado en:Molecules
Autores principales: Dumitrascuta, Maria, Bermudez, Marcel, Trovato, Olga, De Neve, Jolien, Ballet, Steven, Wolber, Gerhard, Spetea, Mariana
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198056/
https://ncbi.nlm.nih.gov/pubmed/34071603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26113267
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