Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial

Ibudilast, a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE)-3, -4, -10, and -11, and macrophage migration inhibitory factor (MIF), shows promise as a novel pharmacotherapy for alcohol use disorder (AUD). However, the mechanisms of action underlying ibudilast’s effects on t...

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Pubblicato in:Transl Psychiatry
Autori principali: Grodin, Erica N., Bujarski, Spencer, Towns, Brandon, Burnette, Elizabeth, Nieto, Steven, Lim, Aaron, Lin, Johnny, Miotto, Karen, Gillis, Artha, Irwin, Michael R., Evans, Christopher, Ray, Lara A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197758/
https://ncbi.nlm.nih.gov/pubmed/34120149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01478-5
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