HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes

Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can strongly influence the expression of genes and endogenous retroviral elements with concomitant dsRNA synthesis and massive transcription of LT...

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Veröffentlicht in:PLoS One
Hauptverfasser: Maksimova, Varvara, Shalginskikh, Natalya, Vlasova, Olga, Usalka, Olga, Beizer, Anastasia, Bugaeva, Polina, Fedorov, Dmitry, Lizogub, Olga, Lesovaya, Ekaterina, Katz, Richard, Belitsky, Gennady, Kirsanov, Kirill, Yakubovskaya, Marianna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195432/
https://ncbi.nlm.nih.gov/pubmed/34115770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0252504
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