HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes

Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can strongly influence the expression of genes and endogenous retroviral elements with concomitant dsRNA synthesis and massive transcription of LT...

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Udgivet i:PLoS One
Main Authors: Maksimova, Varvara, Shalginskikh, Natalya, Vlasova, Olga, Usalka, Olga, Beizer, Anastasia, Bugaeva, Polina, Fedorov, Dmitry, Lizogub, Olga, Lesovaya, Ekaterina, Katz, Richard, Belitsky, Gennady, Kirsanov, Kirill, Yakubovskaya, Marianna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195432/
https://ncbi.nlm.nih.gov/pubmed/34115770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0252504
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