Leveraging the Variability of Pharmacovigilance Disproportionality Analyses to Improve Signal Detection Performances

Background: A plethora of methods and models of disproportionality analyses for safety surveillance have been developed to date without consensus nor a gold standard, leading to methodological heterogeneity and substantial variability in results. We hypothesized that this variability is inversely co...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Khouri, Charles, Nguyen, Thuy, Revol, Bruno, Lepelley, Marion, Pariente, Antoine, Roustit, Matthieu, Cracowski, Jean-Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193489/
https://ncbi.nlm.nih.gov/pubmed/34122089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.668765
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