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Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise to a poorly characterized spectrum of chromosome structural abnormalities. Here, using...
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| Publicado no: | Nat Genet |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8192433/ https://ncbi.nlm.nih.gov/pubmed/33846636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00838-7 |
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