Identification of multiple substrate binding sites in SLC4 transporters in the outward-facing conformation: Insights into the transport mechanism

Solute carrier family 4 (SLC4) transporters mediate the transmembrane transport of HCO(3)(−), CO(3)(2−), and Cl(−) necessary for pH regulation, transepithelial H(+)/base transport, and ion homeostasis. Substrate transport with varying stoichiometry and specificity is achieved through an exchange mec...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhekova, Hristina R., Pushkin, Alexander, Kayık, Gülru, Kao, Liyo, Azimov, Rustam, Abuladze, Natalia, Kurtz, Debra, Damergi, Mirna, Noskov, Sergei Yu, Kurtz, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191340/
https://ncbi.nlm.nih.gov/pubmed/33932403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100724
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