Gain-of-function Tibetan PHD2(D4E;C127S) variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia

BACKGROUND: We have previously described an evolutionarily selected Tibetan prolyl hydroxylase-2 (PHD2(D4E;C127S)) variant that degrades the hypoxia-inducible factor (HIFα) more efficiently and protects these highlanders from hypoxia-triggered elevation in haemoglobin concentration. High altitude is...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Bhattacharya, Sulagna, Shrimali, Nishith M, Mohammad, Ghulam, Koul, Parvaiz A, Prchal, Josef T, Guchhait, Prasenjit
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190441/
https://ncbi.nlm.nih.gov/pubmed/34102396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103418
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