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Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss

Patients with Alzheimer’s disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive. Previously, we found that Tg2576 mice, an AD animal model that ubiquitously expresses Swedish mutant amyloid precursor protein (APP(swe)), shows...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Guo, Hao-Han, Xiong, Lei, Pan, Jin-Xiu, Lee, Daehoon, Liu, Kevin, Ren, Xiao, Wang, Bo, Yang, Xiao, Cui, Shun, Mei, Lin, Xiong, Wen-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190093/
https://ncbi.nlm.nih.gov/pubmed/34108442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-021-00146-0
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