The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor

Spliceosomes are large RNA-protein molecular complexes which mediate splicing of pre-mRNA in eukaryotic cells. Their function is frequently altered in cancer, providing opportunities for novel therapeutic approaches. The ubiquitin specific protease 39 (USP39) is a highly conserved deubiquitylation f...

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Publicat a:Front Oncol
Autors principals: Zhao, Yuan, Geng, Huiwu, Liu, Gang, Ji, Qiang, Cheng, Xiaomin, Li, Xinying, Liu, Wei, Thorne, Rick F., Zhang, Renquan, Liu, Xiaoying
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189149/
https://ncbi.nlm.nih.gov/pubmed/34123832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.667495
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