Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH

In non-alcoholic steatohepatitis (NASH), decreased nitric oxide and increased endothelin-1 (ET-1, also known as EDN1) released by sinusoidal endothelial cells (LSEC) induce hepatic stellate cell (HSC) contraction and contribute to portal hypertension (PH). Statins improve LSEC function, and ambrisen...

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發表在:Dis Model Mech
Main Authors: Bravo, Miren, Raurell, Imma, Barberá, Aurora, Hide, Diana, Gil, Mar, Estrella, Federico, Salcedo, María Teresa, Augustin, Salvador, Genescà, Joan, Martell, María
格式: Artigo
語言:Inglês
出版: The Company of Biologists Ltd 2021
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188885/
https://ncbi.nlm.nih.gov/pubmed/34014280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048884
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