SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in myeloid cells. We investigated the role of SPARC in autoimmunity using the pristane-induced model of lupus that, in mice, mimics human systemic lupus erythematosus (SLE)....

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Vydáno v:iScience
Hlavní autoři: Sangaletti, Sabina, Botti, Laura, Gulino, Alessandro, Lecis, Daniele, Bassani, Barbara, Portararo, Paola, Milani, Matteo, Cancila, Valeria, De Cecco, Loris, Dugo, Matteo, Tripodo, Claudio, Colombo, Mario P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188360/
https://ncbi.nlm.nih.gov/pubmed/34142027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102510
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